twoLayerCascadeK -- an example chemical reaction motif

A combination of two one-site modification cycles in a cascade motif where the phosphotase is not layer specific; that is the same phosphotase acts in both layers [Feliu, Wiuf].

i1 : twoLayerCascadeK()

o1 = S_0+E-->X_1
     X_1-->S_0+E
     X_1-->E+S_1
     S_1+F-->Y_1
     Y_1-->S_1+F
     Y_1-->S_0+F
     S_1+P_0-->X_2
     X_2-->S_1+P_0
     X_2-->S_1+P_1
     F+P_1-->Y_2
     Y_2-->F+P_1
     Y_2-->F+P_0

o1 : ReactionNetwork

In the motif Modification of Two-layer Cascade K, the symbols used in the chemical reactions have the following meaning:

S_i and P_i are substrates with i = 0, 1, 2 phosphorylated sites, E is a kinase and F is a phosphotase, X and Y are the intermediate complexes formed by the enzymes E and F, respectively.

To rename species, use substitute(ReactionNetwork,List).